MANZANERA FERTILITY CLINIC

TREATMENT WITH PLASMA RICH IN GROWTH FACTORS

ENDORET-PRGF | Endogenous Regenerative Technology

This novel technology based on regenerative medicine consists of applying locally the growth factors (Plasma rich in growth factors or PRGF) derived from the patient’s processed blood.
PRGF for the endometrium

The condition of the endometrium is determinant in the assisted reproduction treatments because it must be optimal to favour the implantation.

Research has proven that PRGF infusion can increase the endometrial thickness in patients who have refractory endometrium (not reaching adequate thickness regardless of endometrial preparation with hormones) because the PRGF stimulate the proliferation and secretion of biomolecules essential in improving the endometrial tissue. Besides, this infusion improves the biological environment of a lining making it more receptive to embryo implantation and enhancing its reproductive projection.

In what cases is it indicated?
Patients with refractory endometrium
Patients who had implantation failures

The use of PRGF for endometrium is an efficient alternative for patients experiencing implantation failures, i.e., women who do not become pregnant after several transfers with good-quality embryos. In such cases, proven and effective therapeutical options are still limited. PRGF acts in these patients by stimulating endometrial cells which begin secreting more progesterone and oestrogen receptors. This provokes the emergence of more cell adhesion molecules for the embryo.

Advantages of using PRGF in assisted reproduction

AUTOLOGOUS:
PRGF are retrieved from the patient who will receive the infusion. This allows reducing the risk of adverse effects, incompatibility or allergies.

SIMPLE:
Obtaining PRGF is a simple process for the woman because only a blood draw is required. For its part, the infusion of PRGF into the uterus is painless and not complicated. The procedure is performed using a thin catheter guided through the cervix making it like the embryo transfer and does not require anaesthesia.

COMFORTABLE:
Several doses of PRGF are usually obtained from one blood extraction (for separate infusions) and can be frozen.

 

PRGF – ENDORET® technique to improve the condition of the endometrium or to work on low ovarian reserve can open new roads to recovering fertility.

Optimal embryo implantation. One step ahead in fertility treatments

Plasma obtained from blood contains an optimal concentration of proteins and growth factors which enhance the regeneration and improve the usual clinical treatment results.

PRGF for the ovaries
PRGF can be inoculated in ovaries to favour the regeneration of the ovarian tissue. Although this technique is still more experimental compared to PRGF for the endometrium, the intention is to recover the function of the ovaries by stimulating follicle development.
In what cases is it indicated?
Patients with low ovarian reserve
Patients with primary ovarian insufficiency

This technique must be conducted after prior individual assessment (women under 42 and taking into account the AMH level of a patient).

The ovarian rejuvenation technique is not meant to “rejuvenate” the ovaries but to attempt to achieve more oocytes. This is a solution to recuperate the ovarian function by stimulating the follicle development.