Mitochondria are some formations in the cells, where energy is produced to perform the different functions of our body, especially for the oocyte, which is the motor cell that will drive the development of a new human being and is vital both for natural reproduction and when In Vitro Fertilization (IVF / ICSI or Egg Donation) is performed.
The genes of the cells are made up of DNA where all the information of the human being is encrypted, the genetic DNA is in the nucleus of the cells. But there is another DNA within mitochondrial level, that is more simple than nuclear DNA because it lacks of several components, especially repair enzymes.
Since the mitochondria produce energy, it is there where more free radicals can appear, which if not neutralized by antioxidant systems, could trigger DNA damage within both the mitochondrial and nucleus levels.
Both the natural reproductive process or the In Vitro Fertilization (IVF / ICSI) requires a significant energy supply, the oocyte being the only provider of this supply, having proven that when it is not adequate, a low ovarian reserve may appear.
The most important mitochondrial nutrients that act as antioxidants and improve their functioning are Coenzyme Q10, Resveratrol and Alpha-Lipoic Acid.
These mentioned preparations exist in pharmacological form but they are also found in common foods, walnuts are rich in Coenzyme Q10, Rioja wine in Resveratrol and spinach, broccoli and yeast extract in alpha lipoic acid.
The habitual intake of the referred foods is associated in In Vitro Fertilization cycles with an increase in the number of good quality embryos and a reduction in the genetic abnormalities of the oocyte.
CONCLUSIONS
It should be noted that apart from the normal nuclear DNA of cells, there is a more rudimentary DNA in the mitochondria, the cellular organ where energy is produced and that its alteration by accumulation of free radicals can lead to alterations in the nuclear DNA and cause malfunction of the ovary causing low ovarian reserve .
There are pharmacological preparations to balance this process and also natural foods in our diet that, if consumed regularly, can serve to improve this system.
We look forward to your questions at https://centromedicomanzanera.com/en/formulario_en/
Gregorio Manzanera
Specialist in gynaecology and obstetrics, infertility and assisted reproduction
IMAGE: Taken from https://www.masscience.com/
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